CML is a neoplastic transformation of the primitive hemopoietic stem cells.CML presents with increased TLC count and low lap score. Diagnosis is made using peripheral smear, flow cytometry or bone marrow biopsy. The incidence of this disease has remained stable for the last decade. We present to you a young male with CML and abnormally high WBC count of 175 000/uL, low LAP score and anemia. Philadelphiahia chromosome (9:22 translocation) is positive.

Wellens’ syndrome is characterized by T wave changes in electrocardiogram (EKG) during a period without pain and with on and off chest pain in the patient. This syndrome represents a pre-infarction stage of left anterior descending (LAD) artery, which can lead to extensive anterior myocardial infarctions (MIs) and life threatening complications without coronary angioplasty. Therefore, it is critical for a physician to recognize Wellens’ syndrome EKG features in order to take appropriate measures for managing the patient to reduce mortality and morbidity.

It is essential that oncological patients treated with antiresorptives or antiangiogenic drugs diagnosed Medication Related Osteonecrosis of the Jaw (MRONJ) must be treated in an interdisciplinary fashion. The patient’s stomatognathic system should be examined preventatively prior to the initiation of antiresorptive drugs in order to avoid pathological buccal manifestations, following the same healthcare clinical protocols used for patients receiving head and neck radiotherapy. Additionally, patients should be informed of the precautions to be taken, including regular dental appointments for oral health assessment. The risk of developing MRONJ should be evaluated according to the type of antiresorptives or antiangiogenic drugs administered and treatment duration. In the case of MRONJ, its fundamental characteristic is positioned in the biochemical particularity of the pharmacokinetic expression of antiresorptive drugs, reversibly (DS) or irreversibly (BPs) inhibiting the functionality of the osteoclast. Therefore, the consideration of invading bone tissue as little as possible and performing resective therapies in cases of systemic infectious spread follows, since its long-term resolution would not be effective because the drug (BPs) has frank accumulation at a distance, a characteristic used by treating doctors and it would not have clinical relevance to suggest its suspension. According to the recommendations of AAOMS; Task Force and AOCMF coincide with the sharing of consensus on minimally invasive manipulations once the necrotic foci have been installed and the preventive attitude prevails of eliminating all septic foci prophylactically before starting therapy with antiresorptive drugs. There are positions with a trend more committed to frank bone manipulation with the aim of evacuating the infectious problem and other more conservative positions in order not to expand drug necrosis volumetrically due to bone accumulation of BPs or DS.

In 1817, James Parkinson first coined the term Paralysis Agitans (An Essay on the Shaking Palsy), Jean-Marie Charcot was the first to coin term Parkinson’s disease (PD). Three most common and obvious symptoms in patients with PD are tremor, rigidity, and bradykinesia. A multidisciplinary team involving neurologists, primary care practitioners, nurses, physical therapists, social workers is used to diagnose PD. Nonpharmacological and pharmacological treatment is given to the patient. However, this disease demands more clinical translational and prognostic research, identifying biomarkers that can help in early diagnosis of the disease and on developing future disease-modifying interventions.

Psychotropic effects of corticosteroids were reported in 1950. Patients treated with high doses of corticosteroids developing dementia-like cognitive changes were identified in 1984. Steroids have adverse effects such as immunosuppression, hypertension, and hyperglycemia, inhibition of wound repair, osteoporosis, metabolic disturbances and glaucoma. It also has psychiatric or side effects on central nervous system, as catatonia, dementia, decreased concentration, agitation, altered sensorium, insomnia, and abnormal behaviors. The aim of this review is to highlight the correlation between the administration of corticosteroids and dementia, giving a useful guide for prescribers including a more careful assessment of risk factors and encourage the use of safer doses of this class of drugs.